The chapel was made to build by Giovanni Pontano in 1492 to the memory of his wife Adriana Sassone. Its structure is of classical rectangular inspiration and it stands on a high basement with pilasters in composite order supporting a simple trabeation.
The exterior presents two marble portals, both of which overhung by inscriptions with the family's coats of arms and small windows bedside which are marble slabs with Latin inscriptions.
The wall behind the altar is frescoed a triptych of the Madonna with St John the Baptist and St John the Evangelist (late 15th century).
The late 15th-century glazed tiled floor is beautifully executed and depicts the Pontano family's and his wife's coats of arms as well as geometric design, vegetable and animal subjects.